Severe foot or leg pain and wounds that won’t heal are symptoms of peripheral artery disease (PAD).

Native Americans are 2X more likely to be amputated than White Americans for PAD.47

There is hope.


Native Americans are 2X more likely to be amputated than White Americans for PAD.47

There is hope.

Learn how to potentially avoid amputation and stay whole. Get a second opinion.

Learn More About PAD

Peripheral artery disease (PAD) affects 20 million Americans.1 Knowing the signs and risk factors help with early detection. This may help broaden treatment options which range from non-invasive to invasive.

Make informed decisions and have open conversations with your physician and get a second opinion if amputation is recommended.

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Native American- New

That may not just be your age catching up to you or “poor circulation.” It could be much worse than it appears. You might have peripheral artery disease, or PAD. Without treatment PAD can lead to intolerable pain, amputation and even death. Find out how you can take a stand against amputation.

Swipe through the photos below to reveal symptoms and click for more information.

Symptoms of PAD

If blood is not easily reaching your toes and feet, those areas will experience a drop in temperature.

One of the first signs of the worst form of PAD, called critical limb ischemia (CLI), can be a nonhealing wound or ulcer.

Aches and pains from PAD are the result of narrowed, hardened arteries in the legs, limiting blood flow to your legs and feet.

With CLI, the obstructed blood flow is so considerable and widespread that nighttime pain attacks in your legs or feet can last minutes to hours long.

You shouldn’t have to cope with painful, heavy legs as a normal part of getting older.

If you notice a strange tingling in your foot, or you feel like your entire leg is on fire, pay attention to what your body is telling you and see a health care professional.

You may notice your skin feels drier than normal, and is an unusual color. Parts of your skin could appear to be more red when you’re sitting or standing. Or, your skin might have an unhealthy paleness when your leg is elevated.

Gangrene can cause your skin to dry or shrivel, and the flesh to turn colors — brown to purple to black — and eventually fall off.

Stop ignoring the signs. Talk to a PAD specialist. Take control of your health.


Raul can’t sleep anymore; the pain is so bad

His leg has been hurting for longer than he might admit. The pain often interrupts his sleep. His only relief is hanging his foot off the edge of the bed.

Raul doesn’t know it, but the pain in his leg might mean he has one of the worst forms of peripheral artery disease (PAD), called critical limb ischemia. The disease narrows and hardens arteries in his legs and feet, limiting blood flow. Symptoms include aches, numbness, and burning sensations.

If left untreated, things can rapidly get worse, including the possibility that his disease could lead to having his leg amputated.9 Fortunately for Raul, there’s a simple, noninvasive test his doctor can do to show if there is a problem with  blood flow to his legs called the ankle-brachial index (ABI).

If left untreated, Raul could develop wounds that won’t heal, an amputation may be required. Does this sound familiar? If you have nighttime leg pain, learn more about other symptoms of PAD and share your concerns with a health care professional.

Raul is not an actual patient. His story is intended to represent part of the population with PAD. Symptoms, treatment options and outcomes may vary.


Diabetes is a powerful risk factor of peripheral artery disease (PAD). It has been linked to increased risk for amputation, including PAD-related amputations, and putting a person’s life at risk.

Americans suffer from PAD1

Many Americans not seeking treatment for PAD6

25% Undergoing Treatment
75% Not Undergoing Treatment

PAD-related amputations annually performed in the U.S.3

greater risk for amputation in people with PAD and diabetes than patients without diabetes12,45

Talk to Your Doctor

Only a health care professional can diagnose you with PAD. Our Symptom Quiz can help guide the conversation about your treatment options.

Download the Symptom Checklist

You can print the checklist out and take it with your doctor to help guide your conversation about PAD.

PAD Treatment Spectrum

Don’t Give Up Hope

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CSI®, Take A Stand Against Amputation®, the Take A Stand “Badge” and Stylized “A” are trademarks of Cardiovascular Systems, Inc.

Learn More About PAD

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